Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium

Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium.

Cell polarity, mitotic spindle orientation and asymmetric division play a crucial role in the self-renewal/differentiation of epithelial cells, yet little is known about these processes and the molecular programs that control them in embryonic lung distal epithelium. Herein, we provide the first evidence that embryonic lung distal epithelium is polarized with characteristic perpendicular cell d...

Retraction: Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development doi: 10.1242/dev.058479.

Publisher's Note: Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium by El-Hashash et al. Development doi:10.1242/dev.058479.

Publisher's Note: Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium by El-Hashash et al. Development This Publisher's Note relates to the article 'Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium' by El-Hashash et al. (doi:10.1242/dev.058479). We have recently bee...

Spindle orientation and asymmetric cell fate

Every organism begins as a single cell. Yet, in multicellular organisms, the progeny of that cell form a dazzling assortment of cell types. Generation of this diversity relies on asymmetric divisions. In contrast with symmetric divisions, which faithfully duplicate the characteristics of the parent cell, asymmetric divisions create two daughters that have different fates or identities. Asymmetr...

Mitotic spindle orientation can direct cell fate and bias Notch activity in chick neural tube

Inheritance of apical membrane is proposed to maintain vertebrate neural stem cell proliferation. However, evidence for this is contradictory. Using direct clonal analysis and live imaging in chick neural tube, we show that divisions that separate apical and basal components generate an apical daughter, which becomes a neuron, and a basal daughter, which rapidly re-establishes apico-basal polar...